重度の場合には菌が血液を介して内臓にまで及ぶこともあり、SCUD(Septicemic cutaneous ulcerative disease:敗血症性皮膚潰瘍性疾患)と呼ばれる敗血症の状態になります。特にエロモナス菌による感染を受けると、肝臓、肺、腎臓、心臓にまで波及し、食欲や活動性も低下し、敗血症を起こして死に至ります〔Wimalasena et al.1994, Pasquale et al.1994, Chen et al.2013, Kaplan 1957,Martinez-Jimenez 2007〕。
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